Pathogen Portal

Image map with pictures of organisms representing five Bioinformatics Resource Centers


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	Explore Infectious Disease via the Disease Triangle Start Exploring Host (Human and Model Organisms) Pathogen Environment/Vector Host-Pathogen Interactions Host-Vector Interactions Pathogen-Vector Interactions Featuring... RNA Rocket Align your Illumina fastQ reads against supported genomes, view supported genomes, and estimate gene expression values using an RNA-Seq Pipeline running on Galaxy. Improvements include: New user interface New reference genomes New tools Pathogen Interaction Gateway Generate a network graph of Protein-Protein Interactions, including Host-Pathogen Interactions, from your custom selection of hosts/vectors, bacteria, viruses, and eukaryotic pathogens. News & Announcements from the BRCs PATRIC in Published Research 16 May 2013-PATRIC Featured Article: Wheeler D, Redding AJ, Werren JH (2013), Characterization of an Ancient Lepidopteran Lateral Gene Transfer. 6 May 2013-EuPathDBWorking with Parasite Database Resources - October 20-25, 2013 3 May 2013-VectorBaseRhodnius prolixus gene set RproC1.1 released 24 Apr 2013-Pathogen PortalPathogen Portal update features Protein-Protein Interaction data and RNA-Seq Pipeline updates 5 Apr 2013-IRDMarch 2013 IRD Release 5 Apr 2013-ViPRNext ViPR Release About the Pathogen Portal The Pathogen Portal supports and links to five Bioinformatics Resource Centers (BRCs). Each BRC specializes in a different group of pathogens, focusing on, but not limited to, pathogens causing (Re-)Emerging Infectious Diseases, and those in the NIAID Category A-C Priority Pathogen lists for biodefense research. The scope of the BRCs also includes Invertebrate Vectors of Human Disease. In addition to supporting, and serving as an entryway to, the BRCs, the Pathogen Portal's scientific focus is integrating host-response data that span the pathogens and vectors supported by the BRCs, thereby moving towards an integrative view of Host-Pathogen-Environment interactions, also known as the Disease Triangle. Originating from plant pathology, the concept of the Disease Triangle provides an ecological view of disease which is increasingly relevant to the Health Sciences. According to this view, disease arises when three criteria are met: an infectious Pathogen; a susceptible Host, and a conducive (to disease) Environment. Because some diseases include invertebrate Vectors as part of their ecology, the Disease Triangle broadly considers Vectors to be a component of the Environment. The Pathogen Portal is developed and maintained by the CyberInfrastructure Division at the Virginia Bioinformatics Institute at Virginia Tech. New data and analysis tools are added regularly. Pathogen Portal's Infectious Disease Triangle perspective supports an integrative understanding of human disease through the study of multiple levels of interactions between a susceptible Host, an infectious Pathogen, and a conducive (to disease) Environment. Originating from plant pathology, this ecological approach is increasingly relevant to health sciences. Because some diseases include invertebrate Vectors as part of their ecology, the Disease Triangle broadly considers Environment to include Vectors. New data and analysis tools are added regularly to Pathogen Portal.